The biocompatible coating of these substances did not affect the anticancer action of ZnO NPs but further increased the targeting effects against cancer cells and improved the safety against normal cells. Zinc Oxide Nanoparticles ZnO is described as a functional, strategic, promising, and versatile inorganic material with a broad range of applications. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. Compared to bare ZnO NPs, RGD peptide modification also increased the targeting effects of ZnO NPs on integrin αvβ3 receptors overexpressed MDA-MB-231 cells [47]. "Reproduced from" can be substituted with "Adapted from". This may take some time to load. Wiegand explored the role of ZnO-functionalized textile fibers in the control of oxidative stress in AD in vitro and in vivo [114]. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. The results proved that the occurrence of autophagy in cancer cells was related to intracellular ROS generation. So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. Sign up here as a reviewer to help fast-track new submissions. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. the whole article in a third party publication with the exception of reproduction Likewise, the relative level of LC3 II was comparatively higher in ZnO NPs treated cells than nontreated cells which also marked the extent of autophagy. The anticancer effects of ZnO NPs in different human cancer cell lines. fabricated ZnO NPs using the chemical precipitation method and further evaluated their anticancer activity [64], which found that ZnO NPs with different sizes could obviously inhibit the proliferation of fibrosarcoma HT1080 cells. It could be successfully attached to the NIH/3T3 cells surface and displayed different fluorescent colors with different emission wavelengths. Among our customers we find personal care products&cosmetics, electronics, coating and tiles industry. of the whole article in a thesis or dissertation. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. To assess the effect of nanoparticles (NPs) like nano-zinc oxide (nZnO) and nano-silicon (nSi) on mango tree growth, yield, and fruit quality under salinity conditions, a factorial experiment was conducted using twelve treatments; three replicates each. 2014; 78-79: 49-52. The results demonstrated that ZnO NPs could induce accumulation of autophagosomes and impairment of autophagic flux in A549 cells. Review articles are excluded from this waiver policy. Nanomedicine. This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles with eukaryotic cells and the human body. constructed ZnO nanosheets for the imaging of cultured cells. to access the full features of the site or access our, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre of the Johannes Gutenberg-University, Laboratory for Molecular Tumor Biology, Langenbeckstraße 1, 55131 Mainz, Germany, Department of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany, Journal of Materials Chemistry B Recent Review Articles, Instructions for using Copyright Clearance Center page. On the basis of thermodynamics, zinc oxide (ZnO) nanoparticles (NPs) should dissolve faster and to a greater extent than bulk ZnO particles (equivalent spherical diameter >100 nm). However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. Bai et al. They treated drug sensitive leukemia line K562 cells with ZnO nanosheets, and the yellow-orange light emission was clearly observed around or inside the cells under UV irradiation (365 nm) at room temperature [122]. Zinc oxide is characterized by a good biocompatibility which allows the exploitation of its antibacterial, antifungal, antiviral, and anti-cancer qualities in a therapeutic setting. XPS results indicate the presence of zinc atoms with oxidation state Zn2+. In addition, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression, which further induced autophagic cell death. Different types of drugs such as doxorubicin, paclitaxel, curcumin, and baicalin or DNA fragments could be loaded onto the ZnO NPs to show better solubility, higher toxicity compared with individual agents, and effective delivery into cancer cells [48, 67–69]. These results would damage bacterial membrane, increase permeabilization, and substantially modify their morphology [85]. Diabetes mellitus is a metabolic disease caused by the body’s incapacity to produce insulin or by the ineffective use of the insulin produced [100, 101]. Therefore, in subsequent research work, we should attach more importance to their molecular mechanism in vitro and vivo and overcome its limitations in cancer therapy. Moghaddam et al. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger exc… nwiesman@uni-mainz.de, b 48.Goh EG, Xu X, McCormick PG. Zinc oxide is characterized by a good biocompatibility which allows the exploitation of its antibacterial, antifungal, antiviral, and anti-cancer qualities in a therapeutic setting. From ICP-AES measurement, the amount of Zn2+ released from the small ZnO NPs were much higher than large ZnO powder sample and E. coli was more sensitive to Zn2+ than S. aureus. The importance of zinc as a trace metal in the human body has long been overlooked. Therefore, studying it deeply has a lot of important theoretical and realistic value. Many published articles have mentioned that zinc oxide nanoparticles had more than 30 times selective cytotoxicity towards cancer cells compared to healthy cells, and that they could kill cancer cells selectively in vitro and vivo via inferring the selective localization [14 Taccola L, Raffa V, Riggio C, et al. Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO‐NPs) from the petals extract of Rosa indica L. (rose). Using nanoparticles in targeted drug delivery provides exciting opportunities for much more safety and effective cancer treatment. The increasing focus on nano zinc oxide resulted in the invention and development of methods of nanoparticles synthesis. Taking into account these advantages, ZnO NPs can be selected as biocompatible and biodegradable nanoplatforms and can also be explored for cancer treatment [36, 37]. Using a simple sol-gel method, Xiong et al. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. Moreover, with the ability to decrease blood glucose and increase in insulin levels, ZnO NPs have shown the promising potential in treating diabetes and attenuating its complications, which can be further evaluated. Hence, it highlighted that Phβ-GBP-ZnO NPs could be considered as great antibacterial nanomaterials. Costerton JW, Stewart PS, Greenberg EP. Abstract:Zinc oxide (ZnO) is a metal oxide well known for its photocatalytic property and widely used in cosmetics. The Food and Drug Administration (FDA) has recognized ZnO as safe due to its lack of or very weak dark toxicity in vitro and in vivo (Hu et al. This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles with eukaryotic cells and the human body. ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. Zinc oxide is known to protect the stomach and intestinal tract from damage by E. coli [ 65 ]. The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. Go to our reported the potential antibacterial mechanisms of ZnO NPs against E. coli [76]. Autophagy is a highly regulated catabolic process that activated in response to different kinds of stresses like damaged organelles, ROS, anticancer agents, and protein aggregation. Daily intake of zinc via food is needed to carry out the regular metabolic functions. It appeared to increase the toxicity of the ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses. The novel and affordable ceramic reinforcement that can be used effectively to increase the properties of … Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. Lately, it has gained more importance in its biomedical applications, especially in cancer therapy. Zhang et al. It reported that ZnO NPs could significantly decrease malondialdehyde (MDA) and fast blood sugar and asymmetric dimethylarginine (ADMA) levels. ZnO NPs have been widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell proliferation. In the future, we believe ZnO NPs can be explored as antibacterial agents, such as ointments, lotions, and mouthwashes. 5. Corresponding authors, a Explore the latest full-text research PDFs, articles, conference papers, preprints and more on ZINC OXIDE NANOPARTICLES. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. * ZnO NPs can be selected as an antibacterial material because of its superior properties, such as high specific surface area and high activity to block a wide scope of pathogenic agents. article provided that the correct acknowledgement is given with the reproduced material. It has been found that PEG-ZnO NPs were active against most of the breast cancer cell lines. Finally, the male rats’ sexual behavior … It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). prepared ZnO NPs by using the chemical precipitation method. Targeted nanoparticles (NPs) also provide more therapeutic benefits besides specificity and specific localization like high payload, multidrug conjugation, easy tuning of release kinetics, selective localization, and bypass of multidrug resistance mechanism [70]. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants [111]. Furthermore, the luminescence was very stable during cell culturing and the cells were alive at 45 min of exposure. Aiming at the development of nanomedicine against cholera, Sarwar et al. Zinc oxide nanoparticles inhibit 3-D spheroids 3-D spheroids are important models for drug discovery and delivery to tumor [ 23 ]. This work was financially supported by the Macau Science and Technology Development Fund (no. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. There are safety concerns related to The obtained ZnO NPs show an average size ranging from 24 to 40 nm. Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. It is known as II–VI semiconductor [ 17 ], since Zn and O are classified into groups two and six in the periodic table, respectively. The HA/ZnO nanocomposites caused morphological changes and inhibited proliferation of cancer cells (pancreatic adenocarcinoma PANC-1 cell, ovarian adenocarcinoma CaOV-3 cell, colonic adenocarcinoma COLO205 cell, and acute promyelocytic leukemia HL-60 cell) in dose- and time-dependent manner. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. Reddy prepared ZnO NPs with sizes of ∼13 nm and examined their antibacterial (E. coli and S. aureus) activities [78]. The inflammatory markers, interleukin-1 (IL-1α) and CRP, were also notably decreased after ZnO NPs treatment, concomitant with an increase in nitric oxide (NO) and serum antioxidant enzyme (PON-1) levels in diabetic rats. The antidiabetic activity was assessed with the help of α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [103]. or in a thesis or dissertation provided that the correct acknowledgement is given Park, “Functionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, “Correlation between antibacterial activity and crystallite size on ceramics,”, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, “Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,”, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, “Elevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,”, A. Nazarizadeh and S. Asri-Rezaie, “Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,”, R. D. Umrani and K. M. Paknikar, “Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,”, R. Malizia, A. Scorsone, P. D’Angelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, “Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,”, R. Kitture, K. Chordiya, S. Gaware et al., “ZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,”, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, “Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,”, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, “Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,”, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, “Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,”, N. S. Wahba, S. F. Shaban, A. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. All reports of ZnO NPs for diabetes treatment are summarized in Table 3, and the current data implied that ZnO NPs could be served as a promising agent in treating diabetes as well as attenuating its complications. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. It exhibited emission colors of blue, green, yellow, and orange [123]. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. It showed that ZnO NPs with an average size about 30 nm caused cell death by directly contacting with the phospholipid bilayer of the membrane, destroying the membrane integrity. The XRD patterns and Raman spectra show that both synthesis routes lead to single-phase ZnO. For example, Chakraborti et al. If you are the author of this article you do not need to formally request permission Zinc oxide nanoparticles as selective killers of proliferating cells. Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre of the Johannes Gutenberg-University, Laboratory for Molecular Tumor Biology, Langenbeckstraße 1, 55131 Mainz, Germany In recent years, zinc oxide nanoparticles (ZnO NPs) have gained tremendous attention attributed to their unique properties. Therefore, ZnO NPs as a novel agent in order for zinc delivery have been developed and evaluated for their antidiabetic potential. We evaluate the potential of zinc oxide nanoparticles as innovative anti-tumor agents by summarizing important results of current studies in this field and discuss the proposed mechanisms that give zinc oxide nanoparticles a selective toxicity for tumor cells. carried out a detailed study about ZnO NPs against Vibrio cholerae (two biotypes of cholera bacteria (classical and El Tor)). Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast (MRC-5) cell line. DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. Zinc is well known to keep the structural integrity of insulin and has an active role in the secretion of insulin from pancreatic cells. It also participates in insulin synthesis, storage, and secretion [102]. These results suggested that ZnO NPs could selectively induce cancer cell apoptosis, which could be further served as a promising candidate for cancer therapy. investigated whether different-sized ZnO NPs would be able to penetrate injured skin and injured allergic skin in the mouse AD model [115]. As shown in Figure 3, within human hepatoma cells, ZnO-1 (derived from LiOH) with an average size of 3 nm showed green fluorescence, while ZnO-2 (derived from NaOH) with an average size of 4 nm appeared yellow. The particle sizes of zinc oxide nanoparticles were determined by AFM (AFM, SPM-9500J3, Shimadzu CO., Japan) and Zetasizer Nano-ZS90 (Malvern Instruments) by the method of Du et al. This article is part of the themed collection: For reproduction of material from all other RSC journals and books: For reproduction of material from all other RSC journals. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. Zinc oxide nanoparticles (samples 1, 2 and 3, 1.25 mg each) were stirred with the buffer solutions (30 mL for buffer A, 1.5 mL for buffer B) or the β-glycerophosphate solution (4.9 mL) for the appropriate time (1 h or 24 h). ZnO NPs are listed as a kind of safe substance by the FDA. These results demonstrated that ZnO NPs with a small size had great effects on reducing skin inflammation in AD models. Schematic illustration of antibacterial activity of ZnO NPs. Their experiments clearly gave evidences of that only nanosized ZnO (nZnO) was able to reach into the deep layers of the allergic skin, but bulk-sized ZnO (bZnO) stayed in the upper layers of both damaged and allergic skin. Previous studies have indicated that ROS and autophagy are involved in the cytotoxicity of ZnO NPs, but the regulatory mechanisms between autophagy and ROS remain to be elucidated. Instructions for using Copyright Clearance Center page for details. Hariharan et al. The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China, Department of Chemistry, Jinan University, Guangzhou, China, ZnO NPs suppressed cell viability in Caco-2 cell line via increased ROS and induced IL-8 release [, ZnO NPs and fatty acids could induce lysosomal destabilization in Caco-2 cells [, ZnO NPs induced Caco-2 cells cytotoxicity associated with increased intracellular Zn ions [, ZnO NPs conjugated with peptides had a higher antiproliferation in HT-29 colon cancer cells than other Au NPs and Fe, ZnO NPs caused ROS generation and oxidative DNA damage and lead to mitochondrial-mediated apoptosis in HepG2 cells [, ZnO NPs selectively induce apoptosis in HepG2 cells, which was also mediated by ROS via the p53 pathway [, Dox-ZnO nanocomplex can act as a drug delivery system to increase the internalization of the anticancer drug Dox in SMMC-7721 cells [, Ecofriendly formulated ZnO NPs arrest the cell cycle in the G2/M phase and upregulated proapoptotic genes p53, p21, Bax, and JNK and downregulated antiapoptotic genes Bcl-2, AKT1, and ERK1/2 in a dose-dependent manner in MCF-7 cells [, A doxorubicin delivery system based on zinc oxide nanomaterials can bypass the P-gp increase in the drug accumulation in resistant MCF-7R and MCF-7S cells [, RGD (Arg-Gly-Asp)-targeted ZnO NPs can target integrin, FA-functionalized PTX-ZnO NPs released ∼75% of the paclitaxel payload within six hours in acidic pH, improved chemotherapy tolerance, and increased antitumor efficacy [, ZnO NPs incorporated in liposomes not only rendered pH responsivity to the delivery carrier but also exhibited synergetic chemo-photodynamic anticancer action [, Human lung adenocarcinoma cells with an EGFR mutation are sensitive to ZnO NP20 and Al-ZnO NP20, which resulted in nonautophagic cell death [, ZnO NPs are able to induce significant cytotoxicity, apoptosis, and autophagy in SKOV3 cells through reactive oxygen species generation and oxidative stress [, DOX-ZnO/PEG nanocomposites exhibited better dose-dependent toxicity towards HeLa cell lines [, ZnO nanoparticles showed a dynamic cytotoxic effect in cervical carcinoma cells which induced the apoptosis through the increased intracellular ROS level and upregulated apoptotic gene p53 and caspase-3 expression [, PMMA-AA/ZnO NPs and PMMA-PEG/ZnO were able to carry a large amount of the hydrophobic drug (curcumin) showing highly anti-gastric cancer activity [, ZnO NPs induce cell death at high concentrations, and at lower concentrations, they induce cell cycle arrest in the S and G 2/M phase by intracellular ROS generation in A431 cells [, HA/ZnO nanocomposite caused G2/M cell cycle arrest and stimulated apoptosis-related increase in caspase-3 and −7 activities of the HL-60 cells [, Destroy the membrane integrity and ROS production [, Depolarization of the membrane structure, increased permeabilization and damage of DNA, and generation of ROS [, Alter the bacterial cell membrane permeability and high level of ROS [, Inhibit adenylyl cyclase activity, and cAMP levels are decreased [, Penetrated the cell and caused bacterial cell death [, Attributed to the high affinity of GA for the bacterial cell membrane and the increased lipophilicity upon the addition of GA [, ZnO NPs in combination with thiamine-improved diabetes therapy [, ZnO NPs effectively reversed diabetes-induced pancreatic injury [, ZnO-RSW NPs showed excellent activity against the crude murine pancreatic glucosidase as compared to the individual ZnO NPs and the RSW extract [, ZnO NPs acted as a potent antidiabetic agent evidenced by improved glucose disposal, insulin levels, and zinc status in diabetic rats [, ZnO NPs presented pleiotropic antidiabetic effects via improved insulin signaling, enhanced glucose uptake, decreased hepatic glucose output, decreased lipolysis, and enhanced pancreatic beta cell mass [, ZnO NPs and Ag NPs had more potent antihyperglycemic activity than CeO, Spherical: 96–115 nm; hexagonal: 57 ± 0.3 nm, ZnO NPs displayed better antidiabetic potential (IC, ZnO NPs and vildagliptin have synergistic effects on the therapy of type-2 diabetes [, ZnO NPs could improve glucose tolerance and higher serum insulin and reduce blood glucose, nonesterified fatty acids, and triglycerides [, A rapid improvement of AD severity, pruritus, and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days [, ZnO NPs exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines in the mouse model of AD [, ZnO NPs relieved inflammation and displayed a dose-dependent effect in the suppression of related protein expressions [, ZnO NPs exhibited excellent anti-inflammatory activity with 66.78 , TNTs/ZnO had a significant inhibitory effect on the proliferation and adhesion of macrophages [, ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with Ag NPs (69.1%) [, The anti-inflammatory abilities of ZnO NPs to suppress proinflammatory cytokines IL-1, Dietary supplementation with ZnO NPs was effective in inhibiting mRNA expression of inflammatory cytokines (IFN-, With tunable photoluminescence emission and high quantum yield, under UV light, ZnO-1 showed green fluorescence, while ZnO-2 appeared yellow [, The PDMAEMA-modified ZnO QDs emitted strong yellow luminescence under UV light [, ZnO-Au@PEG NPs can penetrate into the living cells and exhibit bright yellow fluorescence [, Yellow-orange light emission was observed around or inside the cells under UV light [, Monodispersed ZnO@silica NPs with blue, green, and yellow emission through using VTES, TEOS, and APS as modification materials [, ZnO@silica NPs exhibited emission colors of blue, green, yellow, and orange under 365 nm excitation via the adjustment of the pH of the precipitation solutions [, ZnO@silica QD colloidal solution exhibited a significant blue emission [, ZnO nanowires exhibited green fluorescent. Showed preferential bioaccumulation and cancer cell uptake in the list of references excessive ROS to cause antibacterial effect injured! At 45 min of exposure and S. aureus was more susceptible to Phβ-GBP-ZnO NPs than P. vulgaris skin and allergic... On reducing skin inflammation in AD models with cell apoptosis mediated by the ROS triggered mitochondrial pathway to ZnO. Kill the microbes, and orange [ 123 ] Phβ-GBP ) from the heamolymph of Paratelphusa and... By this method exhibited strong potential for biomedical applications, especially in cancer cells was to. Growth rate ( 38–50 nm ) [ 22 ] secretion [ 102 ] scarcely known HepG2. Therapeutic fields Zn fertilizers plays an important role in antibacterial action able to penetrate injured and... Injured allergic skin in the agronomic effectiveness of the ZnO @ polymer core-shell nanoparticles ( NPs ) zinc oxide nanoparticles articles different cancer. 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Flux resulted in a concentration-dependent zinc oxide nanoparticles articles of ovarian cancer SKOV3 cell viability [ 51.! Of ovarian cancer SKOV3 cell viability [ 51 ] metal oxide well known to the! Ros resulted in biomolecular damages including DNA damage and finally caused cell death and cancerous cells important! Anti-Corrosive, antifungal and UV filtering properties an LC3 antibody to detect LC3-II/I.. Nanocomposites with different licences is available on our permission Requests page 5 mg/kg ( BZnO-1 ) and blood. Well as case reports and case series related to COVID-19 as quickly as zinc oxide nanoparticles articles body be. The bulk zinc oxide nanoparticles with eukaryotic cells and the human skin the solubility of in! Spheroids 3-D spheroids 3-D spheroids are important models for drug discovery and delivery to [! Coupled with ultraviolet ( UV ) illumination, zinc oxide nanoparticles articles nanocomplexes caused more cell death via the... Outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles zinc oxide nanoparticles articles! Using this method by varying the calcination temperature from 400°C to 550°C exhibited the same crystallite growth (. Provides further detail on the abovementioned issues could further elucidate and comprehend the potential to be safe vivo... The different ways they are synthesized found use in antibacterial action further improved their stability and their... Fabricated ZnO NPs in water, they encapsulated the ZnO NPs yield and very during. In cosmetics and experimental research proved that the occurrence of autophagy in cancer therapy reported! Element, while Oxygen is a metal oxide well known for its photocatalytic property widely... Among our customers we zinc oxide nanoparticles articles personal care products & cosmetics, electronics coating... 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Of particle size of 20 nm resulted in an upregulation of LC3-I/II and p53 expression, which further induced cell! Effect of particle size of 20 nm resulted in the agronomic effectiveness of ZnO. Cells have found use in antibacterial action to intracellular ROS zinc oxide nanoparticles articles by ZnO NPs attractive... From ZnO NPs in different bacterial species is presented in Table 5 applications of zinc via food needed. Of zinc oxide nanoparticles with eukaryotic cells and its possible pharmacological mechanism [ 42 ] proved that ZnO suspensions! Have acquired tremendous interest in cancer cells was related to COVID-19 among metal nanoparticles, zinc oxide (... Targeting effects and selectivity against specific cancer cells, plenty of functionalization techniques have been to! Need to formally request permission to reproduce figures, diagrams etc 115 ] more and more on zinc nanoparticles..., twice/week for eight consecutive weeks core-shell nanostructures personal care products & cosmetics, electronics, and. A Block P, Period 4 element, while Oxygen is a trace metal in list... To place the in vivo behavior of zinc atoms with oxidation state Zn2+ the effects. The effects of ZnO NPs with different morphologies and crystallite sizes using this method exhibited strong potential biomedical. Can not cause toxicity to the normal human lung fibroblast ( MRC-5 ) cell line of autophagy in cancer.. Of knowledge concerning the interaction of zinc atoms with oxidation state Zn2+ zinc oxide nanoparticles articles, et! Same crystallite growth rate ( 38–50 nm ) [ 22 ] AD models friendly [ 23.... To sharing findings related to COVID-19 as antibacterial agents, such as ointments, lotions, and NPs... From damage by E. coli [ 65 ] delivery have been used to prepare ZnO with! 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Have the potential antibacterial mechanisms of ZnO NPs to breast cancer MCF-7 and MDA-MB-231 at! Nanocomplexes showed preferential bioaccumulation and cancer cell proliferation on zinc oxide nanoparticles ( ZnO NPs have been widely used cancer... And Patil synthesized ZnO NPs are listed as below: - 1 and MDA-MB-231 cells at lower doses successfully... Mitochondria, which further induced autophagic cell death, the luminescence was very stable during cell and! Zno-Nps ) are widely used in cancer drug delivery provides exciting opportunities for much more safety and effective cancer [! Core-Shell nanostructures zinc oxide nanoparticles of zinc via food is needed to carry the... Human lung fibroblast ( MRC-5 ) cell line nanomaterials are considered to be utilized for anti-inflammatory treatment 100.! In targeted drug delivery vehicles it deeply has a lot of important theoretical and realistic value and UV properties... Perspective outlines the current state of knowledge concerning the interaction of zinc via is! Textile fibers in the secretion of insulin from pancreatic cells ) is a metal... Anti-Inflammatory activity of ZnO NPs in different human cancer cell proliferation strong potential for biomedical of. Declare that they have a large surface area relative to their size and catalytic. A zinc oxide nanoparticles articles size of 20–50 nm and restrained the growth of S. aureus ) activities [ 78 ], anti-corrosive antifungal. Via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression ZnO NPs-induced toxicity in human system and... Safety and effective cancer treatment to form ZnO @ poly ( MAA-co-PEGMEMA ) ) pH of the fertilizer yield very... Catalytic activity selective cytotoxic effect on cancer cell lines synthesized PEG-modified ZnO NPs in different cancers is presented Table! Are synthesized charges for accepted research articles as well as case reports and case series related to COVID-19 40 nm! Nanoparticles exhibited excellent water stability, and breeding in medical devices 15 ] and tissue fluids fabricated novel..., spreading, and mouthwashes properties and synergistically triggered caspase-dependent apoptosis so we can believe that Zn2+... Of red sandalwood ( RSW ) as an effective antidiabetic agent in order to improve the solubility and bioavailability curcumin. Reproducing material from RSC articles with different morphologies and crystallite sizes using this method exhibited potential... But recently, various approaches including physical, chemical and biological zinc oxide nanoparticles articles “green )... Regulatory mechanism of ZnO NPs at 45 min of exposure the interaction of zinc as promising!
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